SOX2 and nasal cavity and paranasal sinus carcinoma: Studies reported thus far indicate that high SOX2 levels correlate with poor prognosis for patients with many different cancers, including breast, colorectal, esophageal, ovarian, prostate, and some lung tumors, as well as nasopharyngeal and sinonasal carcinoma (Table 1) [27, 38, 40, 45–48].