Similarly, Ma et al has reported that miR-638, which is expressed at a lower level in colorectal tumors than adjacent non-tumorigenic tissue, is able to target SOX2 [157], and Jin et al reported that miR-450-5p, which is downregulated in recurrent colorectal cancer, is capable of downregulating SOX2 [158]. The gene discussed is SOX2; the disease is colorectal cancer.