One study found SOX2 to be amplified in 26% of serous ovarian cancers [9], and the SOX2 locus (3q26.33) was amplified in ~8% of glioblastoma cases [8], indicating that an increase in copy number is part of the puzzle regarding SOX2 expression in cancer. The gene discussed is SOX2; the disease is ovarian serous adenocarcinoma.