Although the mechanistic relationship between SOX2 expression and SOX2OT remains to be determined, several studies support the conclusion that SOX2OT lncRNA contributes to the expression of SOX2. Knockdown of SOX2OT by siRNA in the lung adenocarcinoma cell line A549 reduced the expression of SOX2 transcripts [173]. The gene discussed is SOX2-OT; the disease is lung adenocarcinoma.