Although SOX2-T118A does not appear to be less stable than wild-type SOX2 in lung squamous cell carcinoma cells, it is possible in some tumor cells that phosphorylation of T118 (human SOX2) may block ubiquitination of SOX2 at K121, as was discussed above for T118 (mouse Sox2), and its influence on the methylation of K119 and the subsequent degradation of Sox2. The gene discussed is SOX2; the disease is squamous cell lung carcinoma.