A number of cancer-related biomarkers of PCa have been identified that may play a role in early PCa detection or prognosis, including: PTEN, PI3K, PCA7 gene panel, PSGR, MME, PSCA, PCA3, TMPRSS2-ERG gene fusion, CD98, EPCA, CD276, prostate-specific membrane antigen (PSMA), caveolin-1, EN-1, and annexin A3 [15]. The gene discussed is EN1; the disease is posterior cortical atrophy.