TNFRSF11A and neoplasm: Indeed, it is noteworthy that not all the cells within BRCA1mut/+ populations are necessarily addicted to the same extent to autocrine/paracrine RANKL/RANK signaling, which appears to necessarily and exclusively operate in those cell states with tumor-initiating capacity since denosumab treatment does not affect cell viability or proliferation of 2D BRCA1mut/+ cultures but efficiently reduces the mammosphere forming capability of CSC-like cellular states, including those that might pre-exist in 2D monolayers.