Moreover, it was recently reported that JAK/STAT pathways upregulate programmed death receptor ligand 1 (PD-L1) in cancer cells, an event that leads to evasion of T cell-mediated antitumor immune responses (Ohaegbulam et al., 2015; Ritprajak and Azuma, 2015). The gene discussed is SOAT1; the disease is cancer.