MAPT and Mental deterioration: Not only because post mortem and initial tau imaging studies indicate that the amount of tau deposition and their topographical distribution in the brain might be more relevant, and more tightly associated with neurodegeneration and cognitive decline than β amyloid deposition [114], but also because in studies of tau model mice using 18F-FEDAA1106 or 11C-Ac-5216, microglial TSPO expression was linked to neurotoxic tau pathology.