Subsequently, this ROS generation leads to an accumulation of defective mitochondria due to an ineffective mitophagy PARK2-dependent mitochondriopathy [24], which is involved in several neurodegenerative diseases such as Parkinson’s disease (PD) [25], Huntington’s disease (HD) [26] and Alzheimer‘s disease (AD) [27]. This evidence concerns the gene PRKN and Alzheimer disease.