AKT1 and lung cancer: Lu et al. reported that melatonin could enhance the antitumor activity of berberine (B in Figure 3) in lung cancer cells by activating caspase/cytochrome c (cyt c) and inhibiting activator protein 2β (AP-2β)/human telomerase reserve transcriptase (hTERT), NF-κB/COX-2 and Akt/ERK signaling pathways as well as increasing the sensitivities of lung cancer cells to berberine (Figure 3) [157].