ROCK1 and neoplasm: Additionally, melatonin showed its oncostatic, antimetastatic and antiangiogenic effects in breast cancer both in vitro and in vivo by blocking proliferation of tumor cells and inhibiting the expression of Rho-associated kinase protein (ROCK-1), one of the regulatory and effector molecules in charge of migration/invasion, which could promote tumor growth and metastasis when its expression was increased [235].