Melatonin at pharmacological concentrations was able to significantly induce apoptosis of colorectal cancer LoVo cells in a dose-dependent manner via histone deacetylase 4 (HDAC4) nuclear import and decreasing H3 acetylation on Bcl-2 promoter, resulting in reduced Bcl-2 expression, which were mediated by inactivating Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) [240]. This evidence concerns the gene HDAC4 and colorectal cancer.