Interestingly, osteonecrosis induced by infectious osteomyelitis plus alendronate administration was significantly blocked in either IL-1α/β (IL-1 KO)- or IL-6-deficient (IL-6 KO) mice, and was weakly attenuated in IL-17A/F-deficient (IL-17 KO) mice (Fig. S9). The gene discussed is IL1A; the disease is osteonecrosis.