Restoration of miR-99a not only dramatically suppresses HCC cell growth, migration and invasion in vitro but also efficiently inhibits tumor growth in vivo by inhibiting mammalian target of rapamycin (mTOR) and Argonaute2(Ago2) signaling, which suggests that miR-99a could be used in targeted HCC treatments13, 15. This evidence concerns the gene MTOR and hepatocellular carcinoma.