Klotho is sensitive to various acute or chronic renal injuries and declined early in renal patients and experimental animals of CKD14, 15, whereas transgenic Klotho over-expression, exogenous Klotho supplementation or the maintaining Klotho via re-activating endogenous Klotho protects against the renal damage and functional loss in CKD animals16, 17, 18, suggesting that Klotho is a remarkable renal protector with therapeutic potentials. Here, KL is linked to chronic kidney disease.