In particular, HDAC1 and 2 are associated with TNFα-incurred acute kidney injury20; abnormal HDAC2 and HDAC4 mediate the pathogenesis of diabetic podocytopathy39, 40 and HDAC1 and HDAC6 contribute to the progression of polycystic kidney disease41, 42. This evidence concerns the gene HDAC1 and medical procedure.