In particular, HDAC1 and 2 are associated with TNFα-incurred acute kidney injury20; abnormal HDAC2 and HDAC4 mediate the pathogenesis of diabetic podocytopathy39, 40 and HDAC1 and HDAC6 contribute to the progression of polycystic kidney disease41, 42. The gene discussed is TNF; the disease is urogenital neoplasm.