Mercimek-Mahmutoglu et al. 48, conducted a retrospective cohort study of 110 patients with intractable epilepsy, global developmental delay, and cognitive dysfunction, Detection rate by targeted next-generation sequencing was 12.7% and SCN1A was the most frequently mutated gene accounting for 29% of 14 variants, which we found similar to our results. Here, SCN1A is linked to Global developmental delay.