Previously reported studies have shown that patients with CDKL5 variants are mainly presented as early onset epileptic encephalopathy (EOEE) with epileptic spasms and severe ID, and suggested that CDKL5 variants should be kept in consideration first in patients showing EOEE with involuntary movements which is being advised by our results which is being enforced by our results28, 30, 46. This evidence concerns the gene CDKL5 and Epileptic spasm.