The linkage between ARX gene variants and SUDEP was previously considered as a potential cause of SUDEP36, but further studies are needed to emphasize this hypothesis, which firmly associated ARX gene variants and severe ID35, variants in this gene have been associated with X-linked severe ID, lissencephaly with abnormal genitalia36, 37, 38, 39, 40, 41. Here, ARX is linked to lissencephaly spectrum disorders.