SCN1A and epilepsy: The detection rate was 18% (46/253) in the whole group and 26% (17/65) in the early-onset (before three months after birth) epilepsy group, in their cohort, patients with an SCN1A variants accounted for the largest proportion, 17% (8/46), which matches our results when we found that SCN1A was the most frequently mutated gene in our study, accounting for 5 (38%) of 13 variants, emphasizing on the linkage between SCN1A variants and EIEE.