SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Variants in SCN1A identified in our study are described as follow: Three de novo pathogenic variants of SCN1A including two novel variants were detected in three cases of Dravet syndrome (C0125, C0129 and R1014), several studies have supported the association of SCN1A gene mutation and Dravet syndrome13, 14, 15.