Manual inspection of the top 10 BC OncoScore genes (Supplementary Table 5) highlighted the presence of at least 5 genes (ABL1, NRAS, ASXL1, RUNX1, IKZF1) that are functionally associated with CML progression7, 8, suggesting that OncoScore was able to correctly prioritize biologically relevant CML cancer genes. This evidence concerns the gene ASXL1 and chronic myelogenous leukemia, BCR-ABL1 positive.