IDH2 and cancer: To test this function, we generated time-series queries spanning from 1975 to 2016 (Fig. 4) and involving two different dataset: 1) a set of manually defined cancer genes (TP53, KRAS, NRAS, HRAS, ASXL1, IDH1, IDH2, TET2, SETBP1) as well as the housekeeping genes GAPDH and GUSB; 2) a set of 10 genes randomly extracted from the CGC (ARID1A, HMGA2, KIF5B, NUP214 and RBM15) and nCan (ALMS1, DCAF17, GPD1L, WFS1 and RBM10) lists.