Others showed a link between activation of epidermal growth factor receptor (EGFR) signaling and upregulation of PD-L1, PD-1, and CTLA-4 in an EGFR-driven murine model of lung cancer and human NSCLC cell lines17 and between activating EGFR mutations and PD-L1 overexpression in tumors18. The gene discussed is CTLA4; the disease is lung carcinoma.