Tyrosine phosphorylation of tau at Tyr18 has also been detected in soluble and detergent-insoluble preparations of FTD brain and in spinal cord from mice expressing human tau with the P301L mutation, which is one of the many tau mutations responsible for the development of frontotemporal lobar degeneration characterised by tau-positive inclusions (FTLD-tau) [490]. The gene discussed is MAPT; the disease is frontotemporal dementia.