MAPT and Alzheimer disease: An N-terminal neurotoxic tau fragment (Tau26–230) termed NH2-tau, has been detected in human SH-SY5Y cells undergoing apoptosis and also in the hippocampus of aged AD11 transgenic mice, which express antibodies to nerve growth factor and exhibit AD-like pathology, including Aβ accumulation and hippocampal-dependent memory deficits [89].