TP53 and obesity due to melanocortin 4 receptor deficiency: These miRNAs were predicted to regulate pathways involved in obesity or in obesity-related cellular dysfunctions, the most significant being adipocytokine and PPAR signaling, some interrelated metabolic pathways (FoxO, cell cycle, MAPK, AMPK, p53, PI3K-Akt, TGF-beta signaling, and apoptosis), the cytoskeleton, and cell-cell adhesion (focal adhesion and tight and adherens junctions).