Interactions of p53/Arf and IFNβ pathways have been shown to play a role in controlling virus infection including through the induction of cell death.11,12 Here we have shown that the presence of the adenoviral vector and the activation of the p53/Arf and IFNβ pathways are critical for the induction of high levels of cell death. This evidence concerns the gene CDKN2A and viral infectious disease.