Given this underlying abnormality in TSC, the possibility of using the mTOR pathway as a therapeutic target has been investigated, namely, using mTOR inhibitors, such as sirolimus (or rapamycin) and everolimus, firstly as an alternative nonsurgical intervention for subependymal giant cell astrocytomas (SEGA) in TSC patients. The gene discussed is MTOR; the disease is tuberous sclerosis.