The relevance of Nrf2 in mesolimbic dopaminergic system has not been fully studied; however, it is known that Nrf2 plays more important role in maintaining normal nigral dopaminergic activity and protects the nigral dopaminergic neurons from neurodegeneration by reducing oxidative stress in Parkinson's disease [56–58]. The gene discussed is NFE2L2; the disease is Parkinson disease.