HMGCR and spindle cell hemangioma: Additionally, SREBP-2 is an important transcriptional regulator of HMGCR expression, and our previous study found that TSH can increase SREBP-2 expression in vitro [14]; we found that the expression of mature SREBP-2 increased in SCH mice compared to the control mice; however, the expression of precursor SREBP-2 had no significant change (Figure 3(e)).