APOE and fatty liver disease: In previous studies, telmisartan induced the increase of serum adiponectin level and the change of morphology (decrease of cell size) of epididymal adipose cells in mice fed high-fat diet [31], irbesartan treatment decreased the GOT level and the diameter of adipocytes in apolipoprotein E knockout mice [32], and as hepatic steatosis increases, the activities of circulating aminotransferases such as GOT and GPT increase proportionally [33, 34].