Additionally, 11β-HSDH1 knockout mice were demonstrated to be resistant to hyperglycemia caused by obesity and stress, and they were shown to have low resistin and TNF-α levels and high PPARγ and uncoupling protein 2 (UCP2) levels compared with these in the control [26]. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.