CTNNB1 and adrenal cortex carcinoma: Moreover, according to our own analysis on two independent datasets (57, 64), BMP4 mRNA is upregulated in ACC samples with nuclear immunostaining for β-catenin or with an activating mutation of CTNNB1 in comparison to those with membranous immunostaining or wild-type for CTNNB1 somatic mutations (fold change >3.21–6.76, FDR-adjusted p-value <0.001).