GlialCAM also binds to Mlc1 (a membrane protein involved in megalencephalic leukoencephalopathy with subcortical cysts, a type of leukodystrophy) and docks both complexes (GlialCAM-ClC-2 and GlialCAM-Mlc1) at cell-cell junctions (López-Hernández et al., 2011; Jeworutzki et al., 2012; Hoegg-Beiler et al., 2014). Here, MLC1 is linked to leukodystrophy.