VCP and amyotrophic lateral sclerosis: This conclusion is further supported by the evidence that a number of genes that participate to the autophagic and proteasomal control of protein degradation, such as ubiquilin-2 (Deng et al., 2011), sequestosome-1 (Fecto et al., 2011), optineurin (Maruyama et al., 2010), valosin-containing protein (VCP; Johnson et al., 2010), TBK1 (Freischmidt et al., 2015) and VAPB (Chen et al., 2010), are associated to ALS.