Similar to dementia with Lewy body, data on exosomes-associated TDP-43, a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, suggest that enhanced exosomes release is beneficial to neuronal survival, in spite of potential increase in disease propagation (Iguchi et al., 2016). The gene discussed is TARDBP; the disease is frontotemporal dementia.