Here, we demonstrated that the predicted G4 sequence in the 5′ UTR of TAOK2 folds into a parallel quadruplex in vitro (Fig. 6B) and a mutation in a patient with colon cancer increases the Tm value of the mutated TAOK2 RNA G4 oligo (Table 1) and decreases the translation efficiency compared to the wild-type (Fig. 6D). The gene discussed is TAOK2; the disease is malignant colon neoplasm.