IFNA1 and Arthritis: Further, while all Charles River rats with mild-moderate and severe arthritis had detectable levels of IFN-ɣ, in Harlan rats 0% of mild-moderate AA cases and 40% of severe AA cases had detectable IFN-ɣ levels, and overall IFN-ɣ levels, while not analyzed statistically, appear to be attenuated in Harlan rats.