In addition, the miRNAs mir466 and mir1186 have 5 potential target genes that are differentially expressed in AMD patients compared to unaffected individuals: lymphocyte cytosolic protein1 (Lcp1), NADPH oxidase 4 (Nox 4) regulator of G-protein signaling (Rgs5), Dystonin (Dst), and Cpm. This evidence concerns the gene NOX4 and age-related macular degeneration.