HPSE and alkaline phosphatase measurement: Serum levels of amylase and lipase typical of AP were increased substantially (3–5 fold) in cerulein-treated WT mice (Fig. 1F,G; green) and even higher ~7 fold induction of lipase and amylase levels was noted in Hpa-Tg mice following cerulein treatment (Fig. 1F,G; red bars), associating with higher levels of heparanase in Hpa-Tg pancreas (Fig. 1C and D, = SST).