Based on the current results, we propose a role in breast cancer predisposition for TEX15 and FANCD2. Of these, FANCD2 has a central role in the Fanconi anemia (FA) DNA repair pathway, which has previously been strongly linked to breast cancer predisposition14, whereas TEX15 represents a novel susceptibility gene among the DDR factors. This evidence concerns the gene FANCD2 and Fanconi anemia.