RAD51C and breast cancer: The prevalence of FANCD2 c.2715 + 1G > A mutation among the studied cohorts supports the previously established link between FA and breast cancer: monoallelic mutations in BRCA2/FANCD1, BRIP1/FANCJ, PALB2/FANCN, RAD51C/FANCO and BRCA1/FANCS genes predispose to breast and/or ovarian cancer, while their biallelic mutations cause FA, characterized by genomic instability, bone marrow failure, developmental abnormalities and increased incidence of cancer, particularly leukemia14, 30, 31.