ARHGAP6 and Intellectual disability: Recently, dysfunction of RhoGAPX-1 and ARHGAP6 has been implicated in a wide range of developmental defects seen in microphthalmia with linear skin defects syndrome[22, 23], while srGAP1, srGAP2, and srGAP3 have been linked to mental retardation, schizophrenia, and seizures[24].