MBD2 and glioblastoma: Because Jmjd3 inhibits sphere formation and proliferation of GBM-SC in a demethylase-dependent manner, we examined the H3K27me3 status at the promoter of a known Jmjd3 and polycomb target gene, myelin transcription factor 1, Myt1 [13], which is a gene that has been implicated in neuronal differentiation [55].