For example, Ly6Chi monocytes control bacterial burdens during Listeria monocytogenes, Klebsiella pneumoniae, and Mycobacterium tuberculosis infection [11–14], in large part because they are an important source of IL-1β, IL-12, and IL-18 during infection and can also differentiate into DCs that produce high levels of TNF [11]. The gene discussed is TNF; the disease is infection.