First, using an enzymatic assay, we confirmed that DENV 2/4 infection increases the HMGCR activity at 24 hpi (DENV2: 1.02 ± 0.0625 U/mg protein, and DENV4: 0.72 ± 0.16 U/mg protein) respect to mock infected cells (0.32 ± 0.01 U/mg protein) (Fig 2A). This evidence concerns the gene HMGCR and infection.