HMGCR and infection: NS3 was detected as evidence of infection (Fig 2A, lower panel). Then, the increase of HMGCR activity was evaluated in DENV infected cells (24 h) treated with DMSO 0.5% (VEH, vehicle), metformin (MET, AMPK activator), and lovastatin (LOV, HMGCR inhibitor) as a positive control.