On the other hand, further experiments are needed to elucidate the potential mechanisms through which other oncogenes implicated in medulloblastoma pathogenesis, such as those in the Wnt and Shh pathways or aberrant epigenetic chromatin modulators (Gajjar and Robinson, 2014; Northcott et al., 2012; Pui et al., 2011), might cause replication stress. The gene discussed is SHH; the disease is medulloblastoma.