Indeed, mutations of the p53 gene are much less common among medulloblastomas (Gajjar and Robinson, 2014; Northcott et al., 2012; Pui et al., 2011) compared to major epithelial cancers or gliomas (Halazonetis et al., 2008; Ranjit et al., 2015). The gene discussed is TP53; the disease is central nervous system cancer.