The striking and fundamental difference upon infection of cells by HCMV in our experiments was that 53BP1 was almost completely mislocalized from the nucleus to the cytosol in the IE72‐expressing, HCMV‐infected BJ normal cells, in sharp contrast to no such relocation, and diffuse 53BP1 expression in IE72‐positive HCMV‐infected medulloblastoma cells, within the HCMV‐infected cultures (Fig. 8). Here, TP53BP1 is linked to infection.