ILC have been shown to play a central role in driving intestinal inflammation in animal models of colitis, and we have previously shown that they accumulate in the inflamed intestine of patients with CD, but not those with UC.20, 25 Interestingly, IL-22-secreting ILC can also drive colitis-associated cancer through the production of IL-22 in murine models.21 Here, IL22 is linked to cancer.