PRKN and Parkinson disease: It is important to note that AIMP2 is found in Lewy body in association with α-synuclein in the brains of PD patient.11, 12 This indicates that AIMP2 is an aggregation-prone protein.32 In the brains of PD patients, parkin activity is compromised, leading to accumulation of its substrate proteins including AIMP2.9, 11, 12, 33 Under this condition, the activity of VPS35 could be critical to prevent abnormal accumulation of AIMP2 and its co-aggregation with α-synuclein.