Integrins is hemidesmosomes allow basal adhesion,24, 25 and their inhibition has been shown to repress the EMT and metastasis in triple-negative breast cancer cells,26 as well as attenuate melanoma cell migration by inducing anoikis.27 We assessed the influence of miR-10a and its targets, MMP14 and ACTG1, on integrins. The gene discussed is ACTG1; the disease is melanoma.