BECN1 and early-onset autosomal dominant Alzheimer disease: For instance, in hippocampal CA1 and cortex regions of PS1/APP mice, a rodent model of Alzheimer's disease (AD), the nuclear concentration of Beclin 1 was detected in a large proportion of neurons, compared with the cytosolic expression of Beclin 1 in the neurons of age-matched control brain (Figure 7b).