KCNB1 and early-onset autosomal dominant Alzheimer disease: The family of Src tyrosine kinases is composed of nine members, including Fyn, which belongs to the SercA sub-family and has been implicated in TBI and Alzheimer's disease, two conditions associated with robust KCNB1 oxidation.8, 9, 17, 25, 26 Therefore, we next sought to determine whether oxidation of KCNB1 resulted in the activation of Fyn using a specific antibody that recognizes phosphorylated tyr530 in Fyn.