MYD88 and Alzheimer disease: DCs are highly specialized professional antigen-presenting cells and are usually located at surveillance interfaces of the human body such as the skin or mucosa, and are thought to have an important role in the initiation and regulation of immune responses, including in AD.37, 38, 39 Here we observed MC903-induced AD was reduced in DC-specific MyD88-deficient mice compared with BL6 mice, suggesting that MyD88 signaling in DCs is critical for AD development.