The IL-1 family cytokine IL-33 (IL-F11) is known to promote Th2 responses and may have an important role in the initiation of AD as the epidermal administration of IL-33 caused an AD-like inflammation.28 However, the function of other IL-1 family cytokines, such as IL-1α, IL-1β, IL-36α/β/γ and IL-36Ra, in the pathogenesis of MC903 AD was not explored before. This evidence concerns the gene IL33 and Alzheimer disease.