Filaggrin gene mutation leads to skin barrier dysfunction and transepidermal water loss, resulting in an AD syndrome.8, 9 The most cited explanations for this allergic disease are an increase in serum immunoglobulin E (IgE) as well as T helper-2 (Th2) immune responses with increased interleukin-4 (IL-4), IL-5, IL-10 and IL-13.6, 7, 10 These phenomena lead to increased allergens exposure, which are picked up by Langerhans cells to lymph nodes and stimulate naive CD4+ T cells (Th0) to differentiate into Th2 cells. The gene discussed is IL4; the disease is allergic disease.