CD4 and Alzheimer disease: First, we investigated the expression of the different IL-1 members in MC903-induced AD and then compared the severity of AD inflammation in BL6 and in gene-deficient mice including IL-1αβ−/−, IL-1R1−/−, IL-36 R−/−, IL-36Ra−/−, IL-33−/−, IL-33 receptor ST2−/−, MyD88−/−, DC-specific MyD88−/− (CD11c-cre × MyD88-floxed) and T-cell-specific MyD88−/− (CD4-cre × MyD88-floxed) mice.