Its main effects on innate and adaptive cells, including ILC2, Th2 cells and alternatively activated M2 polarized macrophages, are consistent with this general function.13, 34 Furthermore, IL-25 and IL-33 drive type 2 ILCs in AD.35 We reported before that DCs respond to IL-33 and contribute to Th2 differentiation in the lung.36 Our data demonstrated that the IL-1 family member IL-33 may be a key factor in MC903-induced experimental AD, and activate DCs favoring Th2 responses in the pathogenesis of this allergic skin disease. This evidence concerns the gene IL1A and Alzheimer disease.