By inducing AD model in BL6 and TSLPR−/− mice, we found MC903-induced AD was markedly decreased in TSLPR−/− mice20 as compared with BL6 mice, including the inflammatory cell infiltration and Th2 cytokine expression, suggesting that TSLP is essential for MC903-induced AD, and IL-33 has a complementary function. This evidence concerns the gene IL33 and Alzheimer disease.