Thus, acetylation of GCM1 increases its stability and transcriptional activity, while sumoylation inhibits the transcriptional activity of GCM1.13 However, studies evaluating the regulation of GCM1 were mostly limited to in vitro work and the functional relevance and (patho-) physiological regulators of GCM1 in human placental disease remain incompletely defined, hampering translational efforts. Here, GCM1 is linked to placenta disorder.