EMT is an important event in tumor progression.51 Many studies have revealed that EMT is regulated by a group of transcription factors, such as Snail, Slug, Twist and ZEB1/2.52, 53 MET describes the reverse process of EMT.54, 55 During tumor progression, EMT mediates the initial transformation from benign to invasive carcinoma, and MET is critical for colonization in the later stages of metastasis. The gene discussed is TWIST1; the disease is neoplasm.