AKT1 and neoplasm: Previous reports have indicated that TGF-β could regulate the growth of hepatocytes through phosphorylation of cPLA2α.29 Furthermore, more evidence has shown that TGF-β induced phosphorylation of PI3K/Akt/mTOR pathway to promote EMT transition.29 In this study, we demonstrated that cPLA2α expression positively correlated with lymph node metastasis, tumor relapse, histological grade and poor prognosis.