PLA2G2A and malignant colon neoplasm: Coincidentally, it has been shown that suppression of cPLA2α expression inhibits tumor cell proliferation in colon cancer.26 Ogawa and co-worders.42 demonstrated that the expression of membrane-associated phospholipase A2 is associated with breast cancer's malignant potency.42 However, the relationship between cPLA2α and breast cancer and the function of cPLA2α in regulating cancer cell metastasis have not been previously investigated.