Recent studies have demonstrated that the transcription factors Ovol1 and Ovol2 act as drivers of MET and a brake on EMT.56 Our previous results demonstrated that the expression of Ovol2 was significantly lower in HCC tissues than in adjacent non-cancerous tissues and correlated with HCC prognosis.57 Our current results showed that in cPLA2α-downregulated cells, the expression of Slug and Twist (EMT-related transcription factors) decreased, whereas the expression of Ovol1 and Ovol2 increased (MET-related transcription factors). This evidence concerns the gene SNAI2 and hepatocellular carcinoma.