Previous reports have indicated that TGF-β could regulate the growth of hepatocytes through phosphorylation of cPLA2α.29 Furthermore, more evidence has shown that TGF-β induced phosphorylation of PI3K/Akt/mTOR pathway to promote EMT transition.29 In this study, we demonstrated that cPLA2α expression positively correlated with lymph node metastasis, tumor relapse, histological grade and poor prognosis. This evidence concerns the gene TGFB1 and neoplasm.