The PI3K/Akt/GSK-3β/β-catenin signaling pathway can regulate the EMT process to influence tumor invasion and metastasis.58 Our study showed that inhibition of PI3K by LY294002 in cPLA2α-overexpressing MDA-MB-231 and T47D cells blocked the phosphorylation of Akt, GSK-3β and FAK. This evidence concerns the gene GSK3B and neoplasm.