To investigate whether repression of CASP1 expression is necessary for G9A-mediated cell invasion and migration, we transiently overexpressed CASP1 in PC9 and A549 cells (Figure 4a), and found that CASP1 overexpression significantly inhibited tumor cell invasion and migration abilities in these cells (Figures 4c–e). Here, CASP1 is linked to neoplasm.