To study the molecular mechanism of G9A-mediated tumor growth and invasion, first, we aimed to identify target genes of G9A in NSCLC cells, by carrying out gene expression correlation analysis in LUAD using the data downloaded from the cbioPortal website, and found that CASP1 expression is negatively correlated with G9A expression in NSCLC (Figure 3a). This evidence concerns the gene EHMT2 and non-small cell lung carcinoma.