ADAMTS15 and osteoporosis: Although the P-value of the rs315096388 marker did not reach a significant threshold for BMD (P-value = 9.85 × 10−7), we hypothesized that this marker had a potential diagnosis on osteoporosis depend on the allelic frequency and the degree of linkage disequilibrium between the SNPs and ADAMTS15 which was the candidate gene with osteoporosis and osteoporotic fractures18.