Moreover, it was suggested that glypican-1 (GPC1)-positive exosomes, derived from cancer cells, may potentially serve as a diagnostic tool to detect early stages of pancreatic tumor [45], and in a follow-up study, the same group suggested that circulating exosomes could be efficiently used for the identification of cancer-driving mutations in PC [46]. This evidence concerns the gene GPC1 and pachyonychia congenita.