Additionally, Goggins and coworkers studied the frequency of biallelic inactivation of BRCA2 in the different stage (from PanIN to invasive pancreatic ductal carcinomas) of PC and reported that the wild-type allele of BRCA2 was lost in high-grade PanIN (PanIN-3), whereas no inactivation was observed in low-grade PanIN (PanIN-1) lesions [101]. Here, BRCA2 is linked to pachyonychia congenita.