In fact, not only does the NF-κB signaling work towards the development/progression of cancer, it helps in the maintenance of the tumor cells, the initiation of metastatic cascades by the direct regulation of MMPs, the induction of angiogenesis through the VEGF signaling in the micro-environment and tissue invasion at distal organs [162,163,201]. The gene discussed is VEGFA; the disease is neoplasm.