Thirteen articles (including 15 independent studies) providing data for 5599 cases and 5863 controls were about the association between TNF-α −238G/A gene polymorphism and IHD risk, while 37 articles (including 44 independent studies) providing data for 15,849 cases and 13,782 controls were on TNF-α −308G/A gene polymorphism. This evidence concerns the gene TNF and myocardial ischemia.