Furthermore, in the subgroup analyses by matching method (A vs G: OR = 1.32, 95% CI = 1.13–1.54), quality (A vs G: OR = 1.23, 95% CI = 1.11–1.37), and HWE (A vs G: OR = 1.14, 95% CI = 1.04–1.25), the results demonstrated that the TNF-α −308A allele was likely to be related to an increasing risk for IHD in the well-designed studies. This evidence concerns the gene TNF and myocardial ischemia.