TNF and myocardial ischemia: The pooled ORs revealed a significant association between TNF-α −308G/A gene polymorphism and IHD risk in allele model (A vs G: OR = 1.22, 95% CI = 1.10–1.35, Fig. 3), dominant model ((AA + GA) vs GG: OR = 1.18, 95% CI = 1.03–1.36), and recessive model (AA vs (GA + GG): OR = 1.37, 95% CI = 1.08–1.75), indicating that the TNF-α −308A allele might be an important risk factor for IHD.