TNF and myocardial ischemia: Most studies were on the gene polymorphisms of TNF-α −238G/A (rs361525), −308G/A (rs1800629), −857C/T (rs1799724), −863C/A (rs1800630), and −1031T/C (rs1799964), while several studies were on the position of −376, −806, +476, +691, respectively.[8,9] Some studies demonstrated that the TNF-α gene polymorphisms could change the susceptibility to IHD.[10,11] However, other studies failed to confirm this relationship.[12,13]