Compared with the meta-analyses conducted by Pereira et al[57] (including 17 studies in 15 articles) and Wang et al[2] (including 36 studies in 28 articles) only analyzing the association between TNF-α −308G/A gene polymorphism and IHD risk, our study had a more sufficient power to investigate the role of TNF-α gene polymorphisms in the risk of IHD, for 45 articles with 32,750 participants were involved. The gene discussed is TNF; the disease is myocardial ischemia.