In the present study, we compared pharmacological inhibition of BAFF (using mouse BAFFR‐Fc, mBAFFR‐Fc), or of BAFF and APRIL (using mouse TACI‐Fc, mTACI‐Fc) in SLE‐prone mice with declared autoimmunity and found that TACI‐Fc, but not BAFFR‐Fc, prevented renal pathology even in the presence of autoantibodies. This evidence concerns the gene TNFRSF13C and systemic lupus erythematosus.