AR and nodular sclerosis classical Hodgkin lymphoma: Since NSHL in these 10 individuals was sporadic and had congenital or prelingual onset, and the most frequent mode of inheritance of NSHL-linked mutations is AR inheritance, we assumed the following inheritance patterns: (1) bi-allelic variants in recessive genes, (2) hemizygous variants in X-chromosome genes in affected male subjects, and (3) de novo heterozygous variants in families in which trio analysis was possible.