As shown in Fig. 6c–g, the mRNA levels of Wnt2b, Wnt4, Wnt5b, Wnt7b, and Wnt10a were increased in the DSH group compared with the DSN group, whereas HCTZ administration decreased the overexpression of Wnt4, Wnt7b, and Wnt10a but did not significantly influence Wnt2b and Wnt5b expression. The gene discussed is WNT7B; the disease is dyschromatosis symmetrica hereditaria.