Furthermore, recent study had showed that SASH1 is showed to be involved in autosomal dominant lentiginous 21 and autosomal‐recessive SASH1 variants are associated with a new genodermatosis with a pigmentation defects, palmoplantar keratoderma 22.Our work herein suggests that hyperpigmentation phenotype of dyschromatosis universalis hereditaria is attributed to three novel SASH1 point mutations. The gene discussed is SASH1; the disease is hereditary palmoplantar keratoderma.