Furthermore, recent study had showed that SASH1 is showed to be involved in autosomal dominant lentiginous 21 and autosomal‐recessive SASH1 variants are associated with a new genodermatosis with a pigmentation defects, palmoplantar keratoderma 22.Our work herein suggests that hyperpigmentation phenotype of dyschromatosis universalis hereditaria is attributed to three novel SASH1 point mutations. This evidence concerns the gene SASH1 and epidermolytic palmoplantar keratoderma, 1.