SAG and schizophrenia: Novel data from the Caron lab (Urs et al. 2016) suggest that ligands such as UNC9994 (Allen et al. 2011), which are partial agonists at the arrestin pathway, exert antipsychotic-like actions in rodent models of schizophrenia by activating the D2R-arrestin pathway preferentially in cortical, as compared to striatal regions, due to the higher expression of beta-arrestin2 in cortex.